Table 1 Mechanisms of action of miRNAs against PRRSV
From: The critical role of miRNAs in modulating PRRSV infection in swine: a review
Articles No | Aims | miRNA | Pathways | References |
|---|---|---|---|---|
1 | PRRSV 3’UTR | miRNA let-7 family | NEAT1 and ARID3A/NF-κB | You et al. 2022 |
2 | LC3B | miR-204 | LC3B-mediated autophagy | Yao et al. 2023 |
3 | FAM134B | miR-142-5P | ER-phagy | Guan et al. 2022 |
4 | TRIM22 | miR-376b-3p | lysosomal pathway | Chen et al. 2022 |
5 | Rac1 | miR-142-3p | downregulating Rac1 expression | Yao et al. 2022 |
6 | IRF 7 | miR-541-3p | negatively regulate the transcription of type I interferon | Shi et al. 2022 |
7 | IRF 1 | miR296-3p | IRF1/TNF-α | Zhang et al. 2021b |
8 | IFNs | miR218 | ↓miR218 → ↓ IFNs → ↑PRRSV | Zhang et al. 2021a |
9 | CD163 receptor | miR181 | ↑miR181 → ↓CD163 | Kang et al. 2021 |
10 | IFNs | miR218 | ↓miR218 → ↓ IFNs | Zhang et al. 2021a |
11 | SPARC/CLIC1/cofilin-1/COX7A2 | miR-27a-5p and 21-3p | ↑miR-27a-5p and 21-3p → ↑PRRSV → ↓SPARC/CLIC1/cofilin-1/COX7A2 | Liang et al. 2020 |
12 | IFNs | miR-382-5p | ↑miR-382-5p → ↑PRRSV → ↓IFNs | Chang et al. 2020 |
13 | The host RXRB | miR-c89 | ↑ miR-c89 → ↓ RXRB → ↓ PRRSV | Zhang et al. 2019b |
14 | THBS/SLC3A1 | miR-339-5p, miR-181d-5p | ↑miR-339-5p → ↓THBS1 → ↓PRRSV ↑miR-181d-5p → ↓SLC3A1 → ↓PRRSV | Zhang et al. 2019a |
15 | PI3K/AKT pathway | miR-27b | ↑ miR-27b → ↓ PI3K/AKT | Wu et al. 2019 |
16 | PI3K/AKT | miR-27b | ↑miR-27b → ↓ PI3K/AKT → ↓PRRSV | Wu et al. 2019 |
17 | CD151 | miR-199a-3p | ↑miR-199a-3p → ↓ CD151 | Zhen et al. 2018 |
18 | IFN | miR-132-3p/miR-335-5p/miR-7-5p | ↑miR-132-3p/miR-335-5p/miR-7-5p → ↓ IFN | Dhorne-Pollet et al. 2019 |
19 | IFNAR2 | miR-30c | ↑miR-30 → ↓IFNAR2 → ↓PRRSV | Liu et al. 2018 |
20 | The host miRNAs | miR-140-3p | ↑miR-140-3p → ↓PRRSV | Li et al. 2018 |
21 | As a biomarker | miR-24-3P | ↓miR-24-3P → ↓PRRSV | Le and Seo 2018 |
22 | IFN-1, MX1 and ISG15 | miR-26, miR-30d | ↑miR-26 → ↓ IFN-1/MX1/ISG1 -↓PRRSV ↑miR-26 → ↓ autophagy/apoptosis -↓PRRSV | Calcatera et al. 2018 |
23 | SRP 14 | miR-10a-5p | ↑miR-10a-5p → ↓SRP14 -↓PRRSV | Zhao et al. 2017 |
24 | IFN-β | miR-373 | ↑miR-373 → ↓IFN-β -↓PRRSV | Chen et al. 2017 |
25 | AKT3 | miR-29 | ↑miR-29 → ↓ AKT3 → ↑ PRRSV | Zhou et al. 2016 |
26 | IFNβ | miR-26a/34a/145 | ↑miR-26a/34a/145 → ↓IFN-β-↓PRRSV | Wang et al. 2018 |
27 | ORF5 of PRRSV | amirGP5-370 | ↑amirGP5-370 → ↓ORF5-↓PRRSV | Xiao et al. 2011 |
28 | TLR4/MyD88/NF-κB | miR-30d-R_1 | ↑miR-30d-R_1 → ↓ TLR4/MyD88/NF-κB-↓PRRSV | Wang et al. 2016 |
29 | The NSP2 sequence | vsRNA1 | ↑ vsRNA1 → ↓ NSP | Li et al. 2016b |
30 | MYH9 | miR-let-7f-5p | ↑ miR-let-7f-5p → ↓ MYH9-↓PRRSV | Li et al. 2016a |
31 | PRRSV 3’ UTR | amiRNA | ↑amiRNA → ↓PRRSV UTR | Zhu et al. 2015 |
32 | The host factor HO-1 | miR-22 | ↑miR-22 → ↓HO-1 → ↑PRRSV | Xiao et al. 2016 |
33 | IFN-I | miR-26a | ↑miR26a → ↓IFN-I → ↓PRRSV | Li et al. 2015b |
34 | PRRSV 5’ UTR | miR130b | ↑miR130b → PRRSV 5’ UTR | Li et al. 2015a |
35 | IFN | miR26a | ↑miR130b → ↑IFN | Jia et al. 2015 |
36 | CD163 | artificial miRNAs | ↑ artificial miRNAs → ↑ CD163 → ↓PRRSV | Zhu et al. 2014 |
37 | TLRS and IFN | miR-145 and 127 | ↑miR-145 → ↓TLRS and IFN → ↑PRRSV ↓miR-127 → ↓MARPK4/Bcl6/CD64 → ↑PRRSV | Zhou et al. 2014 |
38 | IFN | miR-23 | ↑miR-23 → ↓PRRSV → ↑ IFN | Zhang et al. 2014 |
39 | CD151 | miR-506 | ↑ miR-506 → ↓CD151 → ↓PRRSV | Wu et al. 2014 |
40 | Associated with H- and N-PRRSV | miR-125a | miR-125 were high expressed in PAMS during H- and N-PRRSV infection | Cong et al. 2014 |
41 | PRRSV UTR | amiR5UTR, amiR3UTR | ↑amiR5/3UTR → ↓PRRSV UTR | Xia et al. 2013 |
42 | NF-κB | miR-125b | ↑ miR-125b → ↓ NF-κB -↓PRRSV | Wang et al. 2013 |
43 | PRRSV UTR | miR-147 | ↑ miR-147 → ↑PRRSV | J et al. 2013 |
44 | SRP14 | miR-181 | ↑ miR-181 → ↓SRP14 -↓PRRSV | Guo et al. 2013 |
45 | CD163 | miR-181 | ↑ miR-181 → ↓CD163 -↓PRRSV | Gao et al. 2013 |
46 | Heme Oxygenase-1 | miR-24-3p | ↑ miR-24-3p → ↓HO-1 -↑ PRRSV | Xiao et al. 2015 |