Fig. 1

Process of big data analysis and basic information of CHFs and screening of anti-heat stress CHFs. A Process of big data analysis of herbal formulas for the treatment of heat stress. The medicines of the 50 CHFs included in this study were analyzed for (B) four natures, (C) five flavors, and D meridian tropism. E Drug frequency statistics of the drugs in the CHFs included in this study. The greater the frequency of the use of Chinese herbal medicine in the word cloud diagram is, the greater the number of names represented. F Three new CHFs. G Construction of a heat stress mouse model for screening CHFs. H Survival rate of mice under acute heat stress, n=10. I Histological analysis of the hearts, lungs and livers of the mice. The arrows indicate vacuolization and rupture of the myocardium, alveolar septa of the lung, and blood cells invading the liver parenchyma, whereas the pentagonal stars represent alveoli. The control group was given 200 μL of distilled water by gavage, and the doses of F1, F2 and F3 administered were 10 mL/kg. Radar plots were generated via the bioinformatics platform (http://www.bioinformatics.com.cn/), and word cloud plots were generated via the flourish platform (https://flourish.studio/examples/)