Fig. 6

Body reactions of the mice in each group post challenge with EMCV. Note: A. Histopathological section after challenge. The figure displays the pathological characteristics of various tissues collected on day 4. The regions of pathological changes in the tissue are marked with red arrows in the figure. In heart tissue, the red arrows point to foci of coagulative necrosis. In liver tissue, the red arrows signify areas of fatty change (steatosis). In lung tissue, the red arrows denote the presence of ventilation impairment. In kidney tissue, the red arrows indicate features of ballooning degeneration. In brain tissue, the red arrows point to evidence of cerebral edema. B. Expression of inflammatory factors in mouse brain tissue. Group A received treatment 24 h prior to infection, Group B received treatment 24 h after infection, and Group C underwent treatment at intervals of 1, 24, 48 and 72 h post infection. Group D was solely challenged with EMCV, whereas Group E received treatment at 24 and 48 h post infection. Group F served as the control and received only PBS without viral challenge