Therapeutic potential of the neutralizing monoclonal antibody 45G3 against encephalomyocarditis virus

Animal Diseases

Table 1 PISA Interface List

Type	Mol 1				Mol 2				Interface area, Å^2d	ΔⁱG kcal/mol ^e	ΔⁱG P-value^f
Type	Range	ⁱN_at ^a	ⁱN_res ^b	SurfaceÅ^2c	Range	ⁱN_at	ⁱN_res	SurfaceÅ²	Interface area, Å^2d	ΔⁱG kcal/mol ^e	ΔⁱG P-value^f
1	45G3-H2	101	23	6623	45G3-K2	87	24	5601	774.7	−13.2	0.117
2	45G3-H2	77	19	6623	VP1	78	23	17,505	769.1	−2.2	0.605
3	45G3-K2	32	7	5601	VP1	35	13	17,505	307.9	−1.4	0.685

a ⁱN_at indicates the number of interfacing atoms in the corresponding structure
b ⁱN_res indicates the number of interfacing residues in the corresponding structure
c Surface Å² is the total solvent accessible surface area in square Ångstroms
d Interface area in Å², calculated as difference in total accessible surface areas of isolated and interfacing structures divided by two
e ΔⁱG indicates the solvation free energy gain upon formation of the interface, in kcal/M
f ΔⁱG P-value indicates the P-value of the observed solvation free energy gain